Naphthalimide based smart sensor for CN-/Fe3+ and H2S. Synthesis and application in RAW264.7 cells and zebrafish imaging

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dc.contributor.authorNaha, Sanay
dc.contributor.authorWu, Shu-Pao
dc.contributor.authorVelmathi, Sivan
dc.date.accessioned2026-08-24T10:47:36Z
dc.date.available2026-08-24T10:47:36Z
dc.date.issued2020-02-28
dc.description.abstractAchieving selective detection of target analytes in aqueous media continues to be an arduous proposition. Herein, we report the conceptualization and synthesis of a novel tailor-fit molecular probe R based on 1,8-naphthalimide which acts as a trifunctional molecular sensor for CN-, Fe3+ and H2S. R shows colorimetric and fluorometric "on-off" relay recognition for CN- (red colour and orange emission) and Fe3+ (no colour and no emission) in 5% H2O + DMSO medium which is experimentally ascertained to be a tandem deprotonation-protonation process and is supported by 1H-NMR titration. Among all RSS (Reactive Sulphur Species), R shows selectivity for H2S through red colouration. Other coexistent anions, cations and RSS cause no discernible perturbation to the detection process. The detection of H2S is attributed to a chemodosimetric reduction of the nitro to amino group as evidenced by a potentiometric titration assay. The experimental observations are well supported by DFT theoretical calculation. The Ka for CN-/Fe3+ are 1.4 × 104 M-1, 6.07 × 104 M-1 respectively and photochemical yield of R + CN- is 0.86. Limit of detections for CN-, Fe3+ and H2S are 17.5 nM, 8.69 μM and 8.1 μM respectively. Receptor R is effective for real time applications, bio-compatible and has been successfully employed for confocal fluorescence imaging of RAW264.7 cell and zebrafish. This journal is © 2020 The Royal Society of Chemistry.
dc.identifier.issn20462069
dc.identifier.urihttps://doi.org/10.1039/c9ra07998j http://nitt.ndl.gov.in/handle/123456789/236
dc.language.isoen
dc.publisherRoyal Society of Chemistry
dc.relation.ispartofseriesRSC Advances; Vol. 10/ No. 15
dc.titleNaphthalimide based smart sensor for CN-/Fe3+ and H2S. Synthesis and application in RAW264.7 cells and zebrafish imaging
dc.typeArticle
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