Benzodioxole grafted spirooxindole pyrrolidinyl derivatives: synthesis, characterization, molecular docking and anti-diabetic activit

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dc.contributor.authorNivetha, Narayanasamy
dc.contributor.authorMartiz, Reshma Mary
dc.contributor.authorPatil, Shashank M.
dc.contributor.authorRamu, Ramith
dc.contributor.authorSreenivasa, Swamy
dc.contributor.authorSivan, Velmathi
dc.date.accessioned2026-08-23T06:54:52Z
dc.date.available2026-08-23T06:54:52Z
dc.date.issued2022-08-25
dc.description.abstractA highly stereoselective, three-component method has been developed to synthesize pyrrolidine and pyrrolizidine containing spirooxindole derivatives. The interaction between the dipolarophile α,β-unsaturated carbonyl compounds and the dipole azomethine ylide formed in situ by the reaction of 1,2-dicarbonyl compounds and secondary amino acids is referred to as the 1,3-dipolar cycloaddition reaction. The reaction conditions were optimized to achieve excellent stereo- and regioselectivity. Shorter reaction time, simple work-up and excellent yields are the salient features of the present approach. Various spectroscopic methods and single crystal X-ray diffraction examinations of one example of compound 6i validated the stereochemistry of the expected products. The anti-diabetic activity of the newly synthesized spirooxindole derivatives was tested against the α-glucosidase and α-amylase enzymes. Compound 6i was found to exhibit potent inhibition activity against α-glucosidase and α-amylase enzymes which is further evidenced by molecular docking studies. © 2022 The Royal Society of Chemistry.
dc.identifier.urihttps://doi.org/10.1039/d2ra04452h http://nitt.ndl.gov.in/handle/123456789/232
dc.language.isoen
dc.publisherRoyal Society of Chemistry
dc.relation.ispartofseriesRSC Advances; Vol. 12/ No. 37
dc.titleBenzodioxole grafted spirooxindole pyrrolidinyl derivatives: synthesis, characterization, molecular docking and anti-diabetic activit
dc.typeArticle
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