Radical cascade cyclization of amino acid-tethered 1,6-enynones with sulfonyl hydrazides for N-terminal modification: synthesis of functionalized succinimide derivatives

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dc.contributor.authorSivanantham, Mathiyazhagan
dc.contributor.authorJacob Stanley, Jenis
dc.contributor.authorMuthu, Kesavan
dc.contributor.authorVelmathi, Sivan
dc.contributor.authorSenadi, Gopal Chandru
dc.contributor.authorSenadi, Gopal Chandru
dc.contributor.authorRamasamy, Mohankumar
dc.date.accessioned2026-08-23T06:06:56Z
dc.date.available2026-08-23T06:06:56Z
dc.date.issued2025-08-01
dc.description.abstractA metal-free strategy for the N-terminal cyclization of amino acids has been developed by synthesizing highly functionalized succinimide derivatives through radical cyclization of amino acid-tethered 1,6-enynones with sulfonyl hydrazide using NIS and H2O2 as an oxidant. The notable advantages of this work includes time-efficient, good E/Z ratio, moderate to good yields, and was synthesized on a gram-scale. Furthermore, the synthetic utility of the product 5aa was performed by (i) Suzuki coupling reaction with iodo-functionality; and (ii) dipeptide formation using glycine methyl ester. © 2025 The Royal Society of Chemistry.
dc.identifier.issn20462069
dc.identifier.urihttps://doi.org/10.1039/d5ra04754d
dc.identifier.urihttp://nitt.ndl.gov.in/handle/123456789/229
dc.language.isoen
dc.publisherRoyal Society of Chemistry
dc.relation.ispartofseriesRSC Advances; Vol. 15/ No. 34
dc.titleRadical cascade cyclization of amino acid-tethered 1,6-enynones with sulfonyl hydrazides for N-terminal modification: synthesis of functionalized succinimide derivatives
dc.typeArticle
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