Browsing by Author "Sreekanth, Anandaram"

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    Crystal structure of 3-[(E)-(2-hydroxy-3-methoxybenzylidene)amino]-1-methyl-1-phenylthiourea
    (International Union of Crystallography, 2016-04-05) Gangadharan, Rajeswari; Muralisankar, Mathiyan; Sreekanth, Anandaram; Rahman, Abdullakutty Anees; Sethusankar, K
    In the asymmetric unit of the title compound, C16H17N3O2S, there are two independent molecules (A and B), which show an E conformation with respect to the C=N bond. An intramolecular O - H⋯N hydrogen bond with an S(6) motif stabilizes the molecular structure. The terminal phenyl and benzene rings are almost orthogonal to each other, the dihedral angle being 87.47(13)° for molecule A and 89.86(17)° for molecule B. In the crystal, weak bifurcated N - H⋯(O,O) hydrogen bonds link the two independent molecules, forming a supramolecular chain with a C 2 1(14)[R 2 1(5)] motif along the b axis. A weak C - H⋯O interaction is also observed in the chain. © 2016.
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    Host-guest interactions of coumarin-based 1,2-pyrazole using analytical and computational methods: Paper strip-based detection, live cell imaging, logic gates and keypad lock applications
    (Elsevier Ltd, 2024-01-05) Rasin, Puthiyavalappil; Basheer, Sabeel M; Haribabu, Jebiti; Aneesrahman, K.N.; Vadakkedathu Palakkeezhillam, Vishnunarayanan Namboothiri; Bhuvanesh, Nattamai; Echeverria, Cesar; Santibanez, Juan F; Sreekanth, Anandaram
    A novel Coumarin-based 1,2-pyrazole, HCPyTSC is synthesised and characterized. The chemosensor has been shown to have efficient colourimetric and fluorescence sensing capabilities for the quick and selective detection of fluoride and copper ions. At 376 and 430 nm, the HCPyTSC exhibits selective sensing for Cu2+ and F− ions. By examining the natural bond orbital (NBO) analysis and the potential energy curve (PES) of the ground state for the function of the C–H bond, it has been determined from the theoretical study at hand that the deprotonation was taken from the ‘CH’ proton of the pyrazole ring. For F− and Cu2+, the HCPyTSC detection limits were 4.62 nM and 15.36 nM, respectively. Similarly, the binding constants (Kb) for F− and Cu2+ ions in acetonitrile medium were found to be 2.06 × 105 M−1 and 1.88 × 105 M−1. Chemosensor HCPyTSC with and without F− and Cu2+ ions have an emission and absorption response that can imitate a variety of logic gates, including the AND, XOR, and OR gates. Additionally, a paper-based sensor strip with the HCPyTSC was created for use in practical, flexible F− sensing applications. The paper-based sensor was more effective in detecting F− than other anions. The effectiveness of HCPyTSC for the selective detection of F− in living cells as well as its cell permeability were examined using live-cell imaging in T24 cells. © 2024
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    Thiophene anchored two new sets of carbohydrazide for the chemosensing and biological investigation
    (Elsevier B.V., 2023-01-17) Mary Mathew, Merlin; Valappil Rasin, Puthiya; Mandal, Priyabrata; Sreekanth, Anandaram
    The presence of hazardous metal ions or anions in industrial and domestic water may adversely affect the living systems there. Hence their detection is reducing the risk to human and environmental systems. In this study, we investigate the spectroscopical variations of different analytes and the biological performance of two derivatives of carbohydrazide scaffolds. So, we developed two chemosensors 3TCH and BTTCH to detect Cu2+ and F− in an aqueous medium by using photoluminescence spectroscopy (PL). The BTTCH has also sensitively detected the AcO−. Spectral maxima deviations and colour changes in the concentration in concern can serve as indicators of the interaction that was produced. The limit of detection (LOD) was calculated for all the complexes, which all are in lower limits of quantification and the complex 3TCH + F− showed a much lower value of 8.23 × 10−8 M. The binding constants are calculated using the Benesi-Hildebrand equation, 3TCH + F− showed the highest value (K = 9.39 × 10−7M−1) of the association constant, indicating the highest affinity. Additionally, it was investigated whether the chemosensors could be used with common household items like mouthwash and vinegar. © 2023